Dimethyltryptamine (DMT) interactions
Review the current reference classification for Dimethyltryptamine (DMT) paired with medications or other agents represented in the Arcametric reference library.
Reference information only. This resource summarizes information from external sources and isn't individualized medical advice or a determination of treatment suitability.
Interactors with a reference entry
Cardiovascular
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Dimethyltryptamine (DMT) and Propranolol Monitor Only
DMT can acutely raise BP and HR in some contexts. Propranolol blunts HR but not necessarily BP. Propranolol contraindications (asthma, bradycardia) apply.
Evidence: FDA label (Inderal) + mechanistic
GLP-1/GIP Agonist
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Dimethyltryptamine (DMT) and Zepbound (tirzepatide) Insufficient Evidence
No plausible pharmacokinetic interaction for inhaled DMT. Zepbound primarily affects oral absorption and GI tolerability. Monitor for background nausea or hydration confounds only.
Evidence: FDA label (Zepbound 2025) + mechanistic
SSRI/SNRI
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Dimethyltryptamine (DMT) and Pristiq (desvenlafaxine) Clinician Review
No direct evidence. Pristiq has serotonergic and BP warnings. DMT is a serotonergic agonist but not a serotonin releaser — serotonin syndrome risk is theoretical without MAOI exposure. Escalate only if MAOI or harmala exposure present.
Evidence: FDA label (Pristiq 2017) + mechanistic
Return to the Drug Interaction Checker to look up a specific pair, or open the Knowledge library.